Identification of dominant negative rat RAMPs able to inhibit endogenous adrenomedullin receptor function
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چکیده
منابع مشابه
Heterodimers and family-B GPCRs: RAMPs, CGRP and adrenomedullin.
RAMPs (receptor activity-modifying proteins) are single-pass transmembrane proteins that associate with certain family-B GPCRs (G-protein-coupled receptors). Specifically for the CT (calcitonin) receptor-like receptor and the CT receptor, this results in profound changes in ligand binding and receptor pharmacology, allowing the generation of six distinct receptors with preferences for CGRP (CT ...
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ژورنال
عنوان ژورنال: American Journal of Hypertension
سال: 2003
ISSN: 0895-7061
DOI: 10.1016/s0895-7061(03)00139-0